Compound Detail
CHEMBL1090130
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1090130 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CDRBGHJNUBPWFB-BKUYFWCQSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
383.4
MW (Da)
4.87
ALogP
5
HBA
2
HBD
71.7
PSA (Ų)
0.48
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase mTOR CHEMBL2842 | IC50 | 7.02 | 7.02 | 96.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 5.57 | 5.57 | 2665.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase mTOR | IC50 | = | 96.0 | nM | 7.02 | Inhibition of mTOR | 20303263 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 2665.0 | nM | 5.57 | Inhibition of PI3Kalpha | 20303263 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20303263 | 10.1016/j.bmcl.2010.02.082 | Serine/threonine-protein kinase mTOR | 1 |
| 20303263 | 10.1016/j.bmcl.2010.02.082 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 20303263 | 10.1016/j.bmcl.2010.02.082 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 20303263 | 10.1016/j.bmcl.2010.02.082 | No relevant target | 1 |
| 20303263 | 10.1016/j.bmcl.2010.02.082 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine