Compound Detail
CHEMBL1091534
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Basic Information
| ChEMBL ID | CHEMBL1091534 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XVRBIFJEWVZYBQ-CQPUUCJISA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
327.7
MW (Da)
3.85
ALogP
4
HBA
3
HBD
82.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 6.31 | 6.31 | 492.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 5.44 | 5.44 | 3628.0 | 1 |
| Serine/threonine-protein kinase mTOR CHEMBL2842 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 492.0 | nM | 6.31 | Inhibition of PI3Kalpha | 20303263 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 3628.0 | nM | 5.44 | Inhibition of PI3Kgamma | 20303263 |
| Serine/threonine-protein kinase mTOR | IC50 | = | 11000.0 | nM | 4.96 | Inhibition of mTOR | 20303263 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20303263 | 10.1016/j.bmcl.2010.02.082 | Serine/threonine-protein kinase mTOR | 1 |
| 20303263 | 10.1016/j.bmcl.2010.02.082 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 20303263 | 10.1016/j.bmcl.2010.02.082 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 20303263 | 10.1016/j.bmcl.2010.02.082 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine