Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1109912

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.
Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P.
Bioorg Med Chem (2010) 18 : 2566 -2574
PubMed 20303767 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.19 4.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488302 SPIROTRYPROSTATIN B 1 4.68
CHEMBL1089086 DIACETYLBIS(METHYLTHIO)GLIOTOXIN 1 4.25
CHEMBL512683 CHETOSEMINUDIN B 1 4.02
CHEMBL2367464 1 4.01
CHEMBL463268 VERRUCULOGEN 1 4.01
CHEMBL1088849 DEHYDROBIS(METHYLTHIO)GLIOTOXIN 1 -
CHEMBL1089087 1 -
CHEMBL1089088 1 -
CHEMBL1089314 3,6 BISMETHYL(THIOCYCLO)ALANYLTRYPTOPHYL 1 -
CHEMBL331627 GLIOTOXIN 1 -
CHEMBL1089315 VERTICILLIN B 1 -
CHEMBL1088981 BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN 1 -
CHEMBL549475 SPIROTRYPROSTATIN A 1 -
CHEMBL1089800 N-METHYL-6-METHOXYSPIROTRYPROSTATIN B 1 -
CHEMBL1089801 N-METHYLSPIROTRYPROSTATIN A 1 -
CHEMBL1090129 VERRUCULOGEN TR-2 1 -
CHEMBL1089482 FUMITREMORGIN B 1 -
CHEMBL1089971 CYCLOTRYPROSTATIN A 1 -
CHEMBL1089316 CHAETOCIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488302 SPIROTRYPROSTATIN B IC50 = 21100.0 nM 4.68
CHEMBL1089086 DIACETYLBIS(METHYLTHIO)GLIOTOXIN IC50 = 56000.0 nM 4.25
CHEMBL512683 CHETOSEMINUDIN B IC50 = 94900.0 nM 4.02
CHEMBL2367464 IC50 = 97200.0 nM 4.01
CHEMBL463268 VERRUCULOGEN IC50 = 97000.0 nM 4.01
CHEMBL1088849 DEHYDROBIS(METHYLTHIO)GLIOTOXIN IC50 = 141000.0 nM -
CHEMBL1089087 IC50 - -
CHEMBL1089088 IC50 = 125000.0 nM -
CHEMBL1089314 3,6 BISMETHYL(THIOCYCLO)ALANYLTRYPTOPHYL IC50 - -
CHEMBL331627 GLIOTOXIN IC50 < 1000.0 nM -
CHEMBL1089315 VERTICILLIN B IC50 < 600.0 nM -
CHEMBL1088981 BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN IC50 = 140000.0 nM -
CHEMBL549475 SPIROTRYPROSTATIN A IC50 - -
CHEMBL1089800 N-METHYL-6-METHOXYSPIROTRYPROSTATIN B IC50 - -
CHEMBL1089801 N-METHYLSPIROTRYPROSTATIN A IC50 - -
CHEMBL1090129 VERRUCULOGEN TR-2 IC50 - -
CHEMBL1089482 FUMITREMORGIN B IC50 = 104000.0 nM -
CHEMBL1089971 CYCLOTRYPROSTATIN A IC50 - -
CHEMBL1089316 CHAETOCIN IC50 < 600.0 nM -