Assay Detail
Binding
CHEMBL1110024
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Displacement of [3H]citalopram form human SRET by liquid scintillation counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.99 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088000 | — | — | 1 | 9.59 |
| CHEMBL1508 | ESCITALOPRAM | 4.0 | 1 | 9.00 |
| CHEMBL1087817 | — | — | 1 | 8.82 |
| CHEMBL1087818 | — | — | 1 | 8.77 |
| CHEMBL1087455 | — | — | 1 | 8.72 |
| CHEMBL1087585 | — | — | 1 | 8.30 |
| CHEMBL1088560 | — | — | 1 | 7.72 |
| CHEMBL1087744 | — | — | 1 | 7.70 |
| CHEMBL1087743 | — | — | 1 | 7.70 |
| CHEMBL1087745 | — | — | 1 | 7.66 |
| CHEMBL1087872 | — | — | 1 | 7.52 |
| CHEMBL1087454 | — | — | 1 | 7.03 |
| CHEMBL1087453 | — | — | 1 | 7.03 |
| CHEMBL1087452 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088000 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL1508 | ESCITALOPRAM | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1087817 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1087818 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1087455 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1087585 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1088560 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1087744 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1087743 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1087745 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1087872 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1087454 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL1087453 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL1087452 | — | Ki | = | 538.0 | nM | 6.27 |