Assay Detail
Functional
CHEMBL1111994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in rat 3T3 cells after 7 days by alamar blue assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 8.29 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 9.52 |
| CHEMBL1097187 | — | — | 1 | 9.51 |
| CHEMBL1097079 | — | — | 1 | 9.30 |
| CHEMBL1097102 | — | — | 1 | 9.22 |
| CHEMBL1097771 | — | — | 1 | 9.15 |
| CHEMBL1097448 | — | — | 1 | 9.10 |
| CHEMBL1094185 | — | — | 1 | 9.10 |
| CHEMBL1097772 | — | — | 1 | 9.10 |
| CHEMBL1097078 | — | — | 1 | 9.09 |
| CHEMBL1097775 | — | — | 1 | 8.96 |
| CHEMBL1097769 | — | — | 1 | 8.92 |
| CHEMBL1097188 | — | — | 1 | 8.85 |
| CHEMBL1094184 | — | — | 1 | 8.74 |
| CHEMBL1094183 | — | — | 1 | 8.70 |
| CHEMBL1097836 | — | — | 1 | 8.66 |
| CHEMBL1096793 | — | — | 1 | 8.52 |
| CHEMBL1094235 | — | — | 1 | 8.52 |
| CHEMBL1097444 | — | — | 1 | 8.51 |
| CHEMBL1097186 | — | — | 1 | 8.49 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 8.40 |
| CHEMBL1095514 | — | — | 1 | 8.30 |
| CHEMBL1094540 | — | — | 1 | 8.30 |
| CHEMBL1095823 | — | — | 1 | 8.00 |
| CHEMBL1097770 | — | — | 1 | 7.92 |
| CHEMBL343172 | — | — | 1 | 7.77 |
| CHEMBL1097174 | — | — | 1 | 7.57 |
| CHEMBL1094215 | — | — | 1 | 7.48 |
| CHEMBL1097175 | — | — | 1 | 7.16 |
| CHEMBL1094362 | — | — | 1 | 7.08 |
| CHEMBL1096484 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1097187 | — | EC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1097079 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1097102 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1097771 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1097448 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1094185 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1097772 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1097078 | — | EC50 | = | 0.82 | nM | 9.09 |
| CHEMBL1097775 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1097769 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1097188 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1094184 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1094183 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1097836 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1096793 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1094235 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1097444 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1097186 | — | EC50 | = | 3.21 | nM | 8.49 |
| CHEMBL289228 | TIPIFARNIB | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1095514 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1094540 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1095823 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1097770 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL343172 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1097174 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1094215 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1097175 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1094362 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1096484 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1097806 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1096483 | — | EC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1094234 | — | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL1094361 | — | EC50 | = | 320.0 | nM | 6.50 |