Assay Detail
ADMET
CHEMBL1111995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP3A4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.35 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.96 |
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 7.09 |
| CHEMBL1097187 | — | — | 1 | 6.56 |
| CHEMBL1097078 | — | — | 1 | 6.04 |
| CHEMBL1097079 | — | — | 1 | 5.79 |
| CHEMBL1097772 | — | — | 1 | 5.63 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1097187 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL1097078 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL1097079 | — | IC50 | = | 1628.0 | nM | 5.79 |
| CHEMBL1097772 | — | IC50 | = | 2345.0 | nM | 5.63 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4060.0 | nM | 5.39 |