Assay Detail
Functional
CHEMBL1112960
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Inhibition of LPS-induced TNFalpha production in human THP1 cells after 4 hrs by ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.96 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219804 | — | — | 1 | 9.00 |
| CHEMBL94417 | — | — | 1 | 8.40 |
| CHEMBL1098524 | — | — | 1 | 8.25 |
| CHEMBL1098554 | — | — | 1 | 7.62 |
| CHEMBL1096192 | — | — | 1 | 7.59 |
| CHEMBL1098797 | — | — | 1 | 6.75 |
| CHEMBL1098822 | — | — | 1 | 6.58 |
| CHEMBL1098551 | — | — | 1 | 6.57 |
| CHEMBL1098552 | — | — | 1 | 6.37 |
| CHEMBL1098546 | — | — | 1 | 6.02 |
| CHEMBL1098525 | — | — | 1 | 5.19 |
| CHEMBL1096830 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219804 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL94417 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1098524 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1098554 | — | IC50 | = | 23.8 | nM | 7.62 |
| CHEMBL1096192 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL1098797 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1098822 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL1098551 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1098552 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1098546 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1098525 | — | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL1096830 | — | IC50 | = | 6490.0 | nM | 5.19 |