Assay Detail
Binding
CHEMBL1114528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant p38alpha by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.06 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088750 | ARRY-797 | 3.0 | 1 | 8.35 |
| CHEMBL514201 | TALMAPIMOD | 2.0 | 1 | 8.05 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 8.00 |
| CHEMBL1090089 | PAMAPIMOD | 2.0 | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088750 | ARRY-797 | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL514201 | TALMAPIMOD | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1090089 | PAMAPIMOD | IC50 | = | 14.0 | nM | 7.85 |