Compound Detail
CHEMBL1088750
ARRY-797 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL1088750 |
| Name | ARRY-797 |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | IFGWYHGYNVGVRB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
2
Known Names
5
Indications
1
Mechanisms
Molecular Properties
416.5
MW (Da)
4.05
ALogP
5
HBA
1
HBD
59.4
PSA (Ų)
0.60
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| MAP kinase p38 alpha inhibitor | INHIBITOR | Mitogen-activated protein kinase 14 | ✓ | ✓ |
Indications
Cardiomyopathy, Dilated Osteoarthritis, Knee Spondylitis, Ankylosing Toothache Arthritis, Rheumatoid
Activity Summary
IC50 2 meas. best 8.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.35 | 8.35 | 4.5 | 1 |
| Middle East respiratory syndrome-related coronavirus CHEMBL4296578 | IC50 | 6.04 | 6.04 | 913.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 4.5 | nM | 8.35 | Inhibition of human recombinant p38alpha by liquid scintillation counting | 19950901 |
| Middle East respiratory syndrome-related coronavirus | IC50 | = | 913.0 | nM | 6.04 | Antiviral activity against MERS-CoV | 34081439 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 19950901 | 10.1021/jm9012906 | Mitogen-activated protein kinase 14 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 34081439 | 10.1021/acs.jmedchem.1c00335 | Middle East respiratory syndrome-related coronavirus | 1 |
Data from ChEMBL 36 via Core Engine