Assay Detail
Functional
CHEMBL5132016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against MERS-CoV
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Middle East respiratory syndrome-related coronavirus (CHEMBL4296578) ↗| Type | ORGANISM |
| Organism | Middle East respiratory syndrome-related coronavirus |
Publication
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.88 | 6.09 |
| EC50 | 1 | 5.04 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 6.09 |
| CHEMBL2364626 | RALIMETINIB | 2.0 | 1 | 6.06 |
| CHEMBL1088750 | ARRY-797 | 3.0 | 1 | 6.04 |
| CHEMBL472620 | — | — | 1 | 5.33 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL2364626 | RALIMETINIB | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL1088750 | ARRY-797 | IC50 | = | 913.0 | nM | 6.04 |
| CHEMBL472620 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL941 | IMATINIB | EC50 | = | 9230.0 | nM | 5.04 |