Assay Detail
Functional
CHEMBL1114564
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Antiproliferative activity against human HL60 cells after 72 hrs by sulforhodamine B assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.99 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096926 | — | — | 1 | 7.30 |
| CHEMBL1097928 | — | — | 1 | 7.05 |
| CHEMBL1095909 | — | — | 1 | 6.37 |
| CHEMBL1097930 | — | — | 1 | 6.25 |
| CHEMBL1094270 | — | — | 1 | 5.43 |
| CHEMBL1098923 | — | — | 1 | 5.33 |
| CHEMBL1094607 | — | — | 1 | 5.04 |
| CHEMBL1098955 | — | — | 1 | 4.88 |
| CHEMBL1098604 | — | — | 1 | 4.77 |
| CHEMBL1098924 | — | — | 1 | 4.71 |
| CHEMBL1096925 | — | — | 1 | 4.66 |
| CHEMBL1098954 | — | — | 1 | 4.56 |
| CHEMBL1098927 | — | — | 1 | 4.54 |
| CHEMBL1099291 | — | — | 1 | 4.46 |
| CHEMBL1098603 | — | — | 1 | 4.36 |
| CHEMBL1097947 | — | — | 1 | 4.36 |
| CHEMBL1098953 | — | — | 1 | 4.27 |
| CHEMBL1097946 | — | — | 1 | 4.15 |
| CHEMBL1094910 | — | — | 1 | 4.13 |
| CHEMBL1095271 | — | — | 1 | 4.11 |
| CHEMBL1094608 | — | — | 1 | 4.04 |
| CHEMBL1098952 | — | — | 1 | - |
| CHEMBL1095907 | — | — | 1 | - |
| CHEMBL1095906 | — | — | 1 | - |
| CHEMBL1094271 | — | — | 1 | - |
| CHEMBL1099252 | — | — | 1 | - |
| CHEMBL1098270 | — | — | 1 | - |
| CHEMBL1097929 | — | — | 1 | - |
| CHEMBL1097927 | — | — | 1 | - |
| CHEMBL215065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096926 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1097928 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1095909 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1097930 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1094270 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL1098923 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL1094607 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL1098955 | — | IC50 | = | 13170.0 | nM | 4.88 |
| CHEMBL1098604 | — | IC50 | = | 16980.0 | nM | 4.77 |
| CHEMBL1098924 | — | IC50 | = | 19470.0 | nM | 4.71 |
| CHEMBL1096925 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL1098954 | — | IC50 | = | 27460.0 | nM | 4.56 |
| CHEMBL1098927 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL1099291 | — | IC50 | = | 34870.0 | nM | 4.46 |
| CHEMBL1097947 | — | IC50 | = | 43780.0 | nM | 4.36 |
| CHEMBL1098603 | — | IC50 | = | 43780.0 | nM | 4.36 |
| CHEMBL1098953 | — | IC50 | = | 53830.0 | nM | 4.27 |
| CHEMBL1097946 | — | IC50 | = | 71220.0 | nM | 4.15 |
| CHEMBL1094910 | — | IC50 | = | 73200.0 | nM | 4.13 |
| CHEMBL1095271 | — | IC50 | = | 78320.0 | nM | 4.11 |
| CHEMBL1094608 | — | IC50 | = | 91690.0 | nM | 4.04 |
| CHEMBL1095908 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098601 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097257 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098290 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098602 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098925 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL215065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098270 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1099252 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1094271 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1095906 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1095907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098952 | — | IC50 | > | 100000.0 | nM | - |