Assay Detail
Binding
CHEMBL1115144
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.40 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091579 | — | — | 1 | 8.24 |
| CHEMBL1088866 | — | — | 1 | 7.92 |
| CHEMBL521674 | — | — | 1 | 7.62 |
| CHEMBL1091580 | — | — | 1 | 7.54 |
| CHEMBL468565 | — | — | 1 | 7.47 |
| CHEMBL1092638 | — | — | 1 | 7.43 |
| CHEMBL474991 | — | — | 1 | 7.14 |
| CHEMBL1092245 | — | — | 1 | 7.09 |
| CHEMBL1091209 | — | — | 1 | 7.02 |
| CHEMBL1092626 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091579 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1088866 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL521674 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1091580 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL468565 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1092638 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL474991 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1092245 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1091209 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1092626 | — | IC50 | = | 290.0 | nM | 6.54 |