Compound Detail
CHEMBL1088866
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Basic Information
| ChEMBL ID | CHEMBL1088866 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XOVVOPXYEWLASI-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
10
PK Parameters
8
Publications
0
Known Names
Molecular Properties
456.6
MW (Da)
5.15
ALogP
6
HBA
0
HBD
41.6
PSA (Ų)
0.42
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor CHEMBL1855 | IC50 | 8.17 | 7.78 | 6.7 | 2 |
| Gonadotropin-releasing hormone receptor CHEMBL3066 | IC50 | 7.92 | 7.15 | 12.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 685.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 1946.0 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 75.1 | mL.min-1.kg-1 | Rattus norvegicus |
| Cmax | 3863.0 | nM | Rattus norvegicus |
| Cmax | 1725.65 | nM | Rattus norvegicus |
| F | 28.0 | % | Rattus norvegicus |
| T1/2 | 1.1 | hr | Rattus norvegicus |
| T1/2 | 0.1833 | hr | Rattus norvegicus |
| T1/2 | 1.4 | hr | Rattus norvegicus |
| Tmax | 0.8 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | IC50 | = | 6.7 | nM | 8.17 | Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scinti... | 20236823 |
| Gonadotropin-releasing hormone receptor | IC50 | = | 12.0 | nM | 7.92 | Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintill... | 20236823 |
| Gonadotropin-releasing hormone receptor | IC50 | = | 41.0 | nM | 7.39 | Antagonist activity at human recombinant GNRH receptor assessed as inhibition of... | 20236823 |
| Gonadotropin-releasing hormone receptor | IC50 | = | 420.0 | nM | 6.38 | Antagonist activity at GNRH receptor in rat pituitary cells assessed as inhibiti... | 20236823 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20236823 | 10.1016/j.bmcl.2010.02.099 | Rattus norvegicus | 10 |
| 20236823 | 10.1016/j.bmcl.2010.02.099 | Gonadotropin-releasing hormone receptor | 4 |
| 20236823 | 10.1016/j.bmcl.2010.02.099 | No relevant target | 1 |
| 20236823 | 10.1016/j.bmcl.2010.02.099 | ADMET | 1 |
| 20236823 | 10.1016/j.bmcl.2010.02.099 | Liver microsomes | 1 |
| 20236823 | 10.1016/j.bmcl.2010.02.099 | Cytochrome P450 2C9 | 1 |
| 20236823 | 10.1016/j.bmcl.2010.02.099 | Cytochrome P450 2D6 | 1 |
| 20236823 | 10.1016/j.bmcl.2010.02.099 | Cytochrome P450 3A4 | 1 |
Data from ChEMBL 36 via Core Engine