Assay Detail
Binding
CHEMBL1115499
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Inhibition of IGF1R
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.33 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095439 | — | — | 1 | 7.80 |
| CHEMBL1094165 | — | — | 1 | 7.80 |
| CHEMBL1098395 | — | — | 1 | 7.77 |
| CHEMBL1097358 | — | — | 1 | 7.75 |
| CHEMBL1097426 | — | — | 1 | 7.58 |
| CHEMBL1097425 | — | — | 1 | 7.57 |
| CHEMBL1098712 | — | — | 1 | 7.55 |
| CHEMBL1094458 | — | — | 1 | 7.52 |
| CHEMBL1097357 | — | — | 1 | 7.50 |
| CHEMBL1096089 | — | — | 1 | 7.42 |
| CHEMBL1094457 | — | — | 1 | 7.42 |
| CHEMBL1097982 | — | — | 1 | 7.39 |
| CHEMBL1096717 | — | — | 1 | 7.21 |
| CHEMBL1094164 | — | — | 1 | 7.21 |
| CHEMBL401930 | — | — | 1 | 7.00 |
| CHEMBL1098711 | — | — | 1 | 7.00 |
| CHEMBL1078891 | — | — | 1 | 7.00 |
| CHEMBL1097032 | — | — | 1 | 6.76 |
| CHEMBL1099314 | — | — | 1 | 6.68 |
| CHEMBL1095404 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095439 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1094165 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1098395 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1097358 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1097426 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1097425 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1098712 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1094458 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1097357 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1096089 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1094457 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1097982 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1096717 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1094164 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL401930 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1098711 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1078891 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1097032 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL1099314 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1095404 | — | IC50 | = | 270.0 | nM | 6.57 |