Compound Detail
CHEMBL1094164
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Cc1cc(N2CCN(CCC#N)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12
Basic Information
| ChEMBL ID | CHEMBL1094164 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VVIPLSCLYCWUQT-XMMPIXPASA-N |
2
Targets
2
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
532.0
MW (Da)
4.06
ALogP
7
HBA
4
HBD
124.1
PSA (Ų)
0.27
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 7.21 | 7.21 | 61.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 11758.31 | ng.hr.mL-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 61.0 | nM | 7.21 | Inhibition of IGF1R | 20399649 |
| Cytochrome P450 3A4 | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of CYP3A4 assessed as dealkylation of 7-benzyloxy-4-trifluoromethylco... | 20399649 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20399649 | 10.1016/j.bmcl.2010.03.057 | Insulin-like growth factor 1 receptor | 1 |
| 20399649 | 10.1016/j.bmcl.2010.03.057 | Unchecked | 1 |
| 20399649 | 10.1016/j.bmcl.2010.03.057 | Cytochrome P450 3A4 | 1 |
| 20399649 | 10.1016/j.bmcl.2010.03.057 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine