Assay Detail
Binding
CHEMBL1115566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SERT expressed in human JAR cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JAR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.04 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 8.52 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.03 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 7.57 |
| CHEMBL1096495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL637 | VENLAFAXINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1096495 | — | IC50 | > | 2000.0 | nM | - |