Assay Detail
Binding
CHEMBL1115584
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.08 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.41 |
| CHEMBL1094785 | CARMOTEROL | 2.0 | 1 | 8.50 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 7.64 |
| CHEMBL1095777 | INDACATEROL | 4.0 | 1 | 7.12 |
| CHEMBL1095779 | — | — | 1 | 6.95 |
| CHEMBL1095778 | — | — | 1 | 6.92 |
| CHEMBL1094323 | — | — | 1 | 6.66 |
| CHEMBL1094486 | — | — | 1 | 6.47 |
| CHEMBL1094483 | — | — | 1 | 6.28 |
| CHEMBL1094487 | — | — | 1 | 6.16 |
| CHEMBL714 | ALBUTEROL | 4.0 | 1 | 5.74 |
| CHEMBL1095305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL1094785 | CARMOTEROL | Ki | = | 3.19 | nM | 8.50 |
| CHEMBL1256786 | FORMOTEROL | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1095777 | INDACATEROL | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL1095779 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL1095778 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL1094323 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL1094486 | — | Ki | = | 342.0 | nM | 6.47 |
| CHEMBL1094483 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL1094487 | — | Ki | = | 692.0 | nM | 6.16 |
| CHEMBL714 | ALBUTEROL | Ki | = | 1828.0 | nM | 5.74 |
| CHEMBL1095305 | — | Ki | > | 10000.0 | nM | - |