Assay Detail
Functional
CHEMBL1115585
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Agonist activity at human beta2 adrenergic receptor assessed as increase in cAMP level by whole cell assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.04 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.49 |
| CHEMBL1094785 | CARMOTEROL | 2.0 | 1 | 9.12 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 8.89 |
| CHEMBL1094323 | — | — | 1 | 8.30 |
| CHEMBL1095777 | INDACATEROL | 4.0 | 1 | 7.96 |
| CHEMBL1095778 | — | — | 1 | 7.85 |
| CHEMBL1094486 | — | — | 1 | 7.75 |
| CHEMBL1095779 | — | — | 1 | 7.60 |
| CHEMBL1094483 | — | — | 1 | 7.41 |
| CHEMBL714 | ALBUTEROL | 4.0 | 1 | 7.17 |
| CHEMBL1094487 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL1094785 | CARMOTEROL | EC50 | = | 0.76 | nM | 9.12 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1094323 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1095777 | INDACATEROL | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1095778 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1094486 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1095779 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1094483 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL714 | ALBUTEROL | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1094487 | — | EC50 | = | 115.0 | nM | 6.94 |