Assay Detail
Binding
CHEMBL1116587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]5-HT uptake at SERT
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.75 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 7.13 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL43048 | MIDOMAFETAMINE | IC50 | = | 425.0 | nM | 6.37 |