Assay Detail
Functional
CHEMBL1116786
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Neuroprotective activity against glutamate-mediated oxidative stress-induced cell death in mouse HT22 cells assessed as survival after 24 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HT-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.16 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096008 | — | — | 1 | 7.10 |
| CHEMBL1096354 | — | — | 1 | 7.05 |
| CHEMBL3989727 | VITAMIN E | 4.0 | 1 | 6.70 |
| CHEMBL1096355 | — | — | 1 | 6.04 |
| CHEMBL1096007 | — | — | 1 | 6.02 |
| CHEMBL1096005 | — | — | 1 | 5.85 |
| CHEMBL1096006 | — | — | 1 | 5.77 |
| CHEMBL1090054 | — | — | 1 | 5.59 |
| CHEMBL48310 | HINOKITIOL | — | 1 | 5.32 |
| CHEMBL1076937 | — | — | 1 | - |
| CHEMBL1090409 | — | — | 1 | - |
| CHEMBL1084418 | — | — | 1 | - |
| CHEMBL121188 | TROPOLONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096008 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1096354 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3989727 | VITAMIN E | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1096355 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1096007 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1096005 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1096006 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1090054 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL48310 | HINOKITIOL | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1076937 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1090409 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1084418 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL121188 | TROPOLONE | EC50 | > | 10000.0 | nM | - |