Assay Detail
Binding
CHEMBL1119971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Colloid formation by drugs in simulated intestinal fluid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.78 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 5.52 |
| CHEMBL1083993 | AMIODARONE HYDROCHLORIDE | 4.0 | 1 | 5.40 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 5.40 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 5.22 |
| CHEMBL1085699 | MANIDIPINE 6300 | 3.0 | 1 | 5.22 |
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 5.16 |
| CHEMBL1086440 | TRICLABENDAZOLE | 4.0 | 1 | 4.82 |
| CHEMBL259223 | MENATETRENONE | 3.0 | 1 | 4.75 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 4.48 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | 4.0 | 1 | 4.38 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 4.26 |
| CHEMBL672 | FENOFIBRATE | 4.0 | 1 | 4.21 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.06 |
| CHEMBL1084541 | — | — | 1 | 4.01 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | - |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | - |
| CHEMBL1085765 | MECLIZINE DIHCL | — | 1 | - |
| CHEMBL1083385 | CLOPIDOGREL BISULFATE | 4.0 | 1 | - |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | - |
| CHEMBL43064 | CINNARIZINE | 2.0 | 1 | - |
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1083993 | AMIODARONE HYDROCHLORIDE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1085699 | MANIDIPINE 6300 | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL21333 | PRANLUKAST | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1086440 | TRICLABENDAZOLE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL259223 | MENATETRENONE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL672 | FENOFIBRATE | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL939 | GEFITINIB | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL1084541 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL941 | IMATINIB | IC50 | = | 207000.0 | nM | - |
| CHEMBL929 | DELAVIRDINE MESYLATE | IC50 | = | 122000.0 | nM | - |
| CHEMBL1085765 | MECLIZINE DIHCL | IC50 | = | 129000.0 | nM | - |
| CHEMBL1083385 | CLOPIDOGREL BISULFATE | IC50 | = | 123000.0 | nM | - |
| CHEMBL584 | NELFINAVIR | IC50 | = | 144000.0 | nM | - |
| CHEMBL43064 | CINNARIZINE | IC50 | = | 124000.0 | nM | - |
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | IC50 | = | 189000.0 | nM | - |
| CHEMBL118 | CELECOXIB | IC50 | = | 126000.0 | nM | - |