Assay Detail
ADMET
CHEMBL1120512
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Inhibition of CYP2D6
16
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.16 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1084033 | 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | — | 2 | 5.85 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | — | 3 | 5.52 |
| CHEMBL1083426 | 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | — | 2 | 5.51 |
| CHEMBL375131 | — | — | 1 | 5.44 |
| CHEMBL1085567 | — | — | 1 | 4.92 |
| CHEMBL1085959 | — | — | 1 | 4.75 |
| CHEMBL214335 | — | — | 2 | 4.70 |
| CHEMBL403441 | — | — | 1 | 4.52 |
| CHEMBL1080787 | — | — | 1 | - |
| CHEMBL1084971 | — | — | 1 | - |
| CHEMBL1086273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1084033 | 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1083426 | 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1083426 | 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL375131 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1084033 | 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1085567 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL1085959 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL214335 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL403441 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1080787 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1084971 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1086273 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL214335 | — | IC50 | > | 30000.0 | nM | - |