Assay Detail
Binding
CHEMBL1120736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERT-mediated serotonin uptake in human JAR cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JAR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.35 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.03 |
| CHEMBL1085831 | — | — | 1 | 5.69 |
| CHEMBL1083083 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1085831 | — | IC50 | = | 2042.0 | nM | 5.69 |
| CHEMBL1083083 | — | IC50 | = | 4589.0 | nM | 5.34 |