Assay Detail
Functional
CHEMBL1168152
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Cytotoxicity against mouse P388 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of 2,5-bis(3'-indolyl)-furans and 3,5-bis(3'-indolyl)-isoxazoles, nortopsentin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.73 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1164135 | N-METHYL NORTOPSENTIN A | — | 1 | 6.10 |
| CHEMBL1164136 | N-METHYL NORTOPSENTIN B | — | 1 | 6.10 |
| CHEMBL1164324 | — | — | 1 | 6.10 |
| CHEMBL63208 | NORTOPSENTIN C | — | 1 | 5.35 |
| CHEMBL292801 | NORTOPSENTIN B | — | 1 | 5.35 |
| CHEMBL302637 | NORTOPSENTIN A | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1164135 | N-METHYL NORTOPSENTIN A | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1164136 | N-METHYL NORTOPSENTIN B | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1164324 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL63208 | NORTOPSENTIN C | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL292801 | NORTOPSENTIN B | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL302637 | NORTOPSENTIN A | IC50 | = | 4500.0 | nM | 5.35 |