Assay Detail
Functional
CHEMBL1175702
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Cytotoxicity against human Hs578 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hs578 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.65 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 5.72 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 5.16 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 4.92 |
| CHEMBL1172329 | — | — | 1 | 4.60 |
| CHEMBL1171972 | — | — | 1 | 4.40 |
| CHEMBL1171238 | — | — | 1 | 4.29 |
| CHEMBL1172129 | — | — | 1 | 4.27 |
| CHEMBL1171969 | — | — | 1 | 4.26 |
| CHEMBL1170012 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL1172329 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL1171972 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL1171238 | — | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL1172129 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1171969 | — | IC50 | = | 55100.0 | nM | 4.26 |
| CHEMBL1170012 | — | IC50 | = | 55900.0 | nM | 4.25 |