Assay Detail
Functional
CHEMBL1175973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative inotropic activity against potassium-induced contraction in guinea pig left atrium assessed as decrease in developed tension
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.10 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172220 | — | — | 1 | 8.00 |
| CHEMBL640 | PROCAINAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL1173426 | — | — | 1 | 7.77 |
| CHEMBL79 | LIDOCAINE | 4.0 | 1 | 7.77 |
| CHEMBL1173425 | — | — | 1 | 7.75 |
| CHEMBL1170239 | — | — | 1 | 7.64 |
| CHEMBL1172785 | — | — | 1 | 7.51 |
| CHEMBL1173203 | — | — | 1 | 7.47 |
| CHEMBL1173497 | — | — | 1 | 7.46 |
| CHEMBL220709 | — | — | 1 | 7.36 |
| CHEMBL373373 | — | — | 1 | 7.25 |
| CHEMBL1170052 | — | — | 1 | 7.13 |
| CHEMBL1172221 | — | — | 1 | 7.00 |
| CHEMBL1172786 | — | — | 1 | 6.96 |
| CHEMBL1172787 | — | — | 1 | 6.47 |
| CHEMBL1173123 | — | — | 1 | 6.46 |
| CHEMBL219546 | — | — | 1 | 6.34 |
| CHEMBL218853 | — | — | 1 | 6.21 |
| CHEMBL218250 | — | — | 1 | 6.12 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172220 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL640 | PROCAINAMIDE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1173426 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL79 | LIDOCAINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1173425 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1170239 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1172785 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1173203 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1173497 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL220709 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL373373 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1170052 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1172221 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1172786 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1172787 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1173123 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL219546 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL218853 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL218250 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1294 | QUINIDINE | EC50 | = | 3380.0 | nM | 5.47 |