Assay Detail
Functional
CHEMBL1177580
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Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hs 683 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.18 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172881 | HAEMANTHIDINE | — | 1 | 5.37 |
| CHEMBL400092 | LYCORINE | — | 1 | 5.16 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | — | 1 | 5.16 |
| CHEMBL586091 | PSEUDOLYCORINE | — | 1 | 5.10 |
| CHEMBL575533 | AMARBELLISINE | — | 1 | 5.09 |
| CHEMBL575125 | CARANINE | — | 1 | - |
| CHEMBL1172893 | GALANTHINE | — | 1 | - |
| CHEMBL584172 | NORPLUVINE | — | 1 | - |
| CHEMBL479291 | UNGEREMINE | — | 1 | - |
| CHEMBL1173549 | NOBILISITINE B | — | 1 | - |
| CHEMBL1171988 | CLIVONINE HYDROCHLORIDE | — | 1 | - |
| CHEMBL457605 | TAZETTINE | — | 1 | - |
| CHEMBL1173110 | AMBELLINE | — | 1 | - |
| CHEMBL1173111 | BUPHANAMINE | — | 1 | - |
| CHEMBL6067651 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172881 | HAEMANTHIDINE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL400092 | LYCORINE | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL586091 | PSEUDOLYCORINE | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL575533 | AMARBELLISINE | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL575125 | CARANINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1172893 | GALANTHINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL584172 | NORPLUVINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL479291 | UNGEREMINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1173549 | NOBILISITINE B | IC50 | > | 10000.0 | nM | - |
| CHEMBL1171988 | CLIVONINE HYDROCHLORIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL457605 | TAZETTINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1173110 | AMBELLINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1173111 | BUPHANAMINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL6067651 | — | IC50 | > | 10000.0 | nM | - |