Assay Detail
Binding
CHEMBL1211653
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Inhibition of sheep COX1 by enzyme immunoassay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.27 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.52 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.54 |
| CHEMBL1210017 | — | — | 1 | 5.24 |
| CHEMBL1210018 | — | — | 1 | 4.98 |
| CHEMBL1210074 | — | — | 1 | 4.95 |
| CHEMBL1210072 | — | — | 1 | 4.92 |
| CHEMBL1210073 | — | — | 1 | 4.77 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1210017 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1210018 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1210074 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1210072 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL1210073 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL118 | CELECOXIB | IC50 | = | 115900.0 | nM | - |