Assay Detail
Binding
CHEMBL1216984
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Inhibition of human HDAC3
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical phylogenetics of histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.55 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.82 |
| CHEMBL430060 | APICIDIN | — | 1 | 9.59 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.30 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.96 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 8.82 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 8.52 |
| CHEMBL96051 | SCRIPTAID | — | 1 | 8.39 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.38 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.30 |
| CHEMBL353581 | PYROXAMIDE | 1.0 | 1 | 8.10 |
| CHEMBL1213457 | — | — | 1 | 6.92 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 6.90 |
| CHEMBL1213458 | — | — | 1 | 6.60 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 6.58 |
| CHEMBL356769 | TUBACIN | — | 1 | 6.56 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.44 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 6.26 |
| CHEMBL279636 | — | — | 1 | 5.87 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | — | 1 | 5.78 |
| CHEMBL1213459 | DEPUDECIN | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL430060 | APICIDIN | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1213492 | GIVINOSTAT | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL96051 | SCRIPTAID | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL356066 | DACINOSTAT | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL98 | VORINOSTAT | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL353581 | PYROXAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1213457 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL1213458 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL272980 | MOCETINOSTAT | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL356769 | TUBACIN | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL27759 | ENTINOSTAT | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL235191 | TACEDINALINE | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL279636 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | Ki | = | 1650.0 | nM | 5.78 |
| CHEMBL1213459 | DEPUDECIN | Ki | = | 14500.0 | nM | 4.84 |