Assay Detail
Binding
CHEMBL1217098
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Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.03 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119296 | — | — | 1 | 7.36 |
| CHEMBL1214194 | — | — | 1 | 7.33 |
| CHEMBL1214195 | — | — | 1 | 7.32 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL303004 | — | — | 1 | 6.21 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.20 |
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 6.08 |
| CHEMBL25101 | — | — | 1 | 5.99 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | 5.91 |
| CHEMBL1214248 | — | — | 1 | 5.90 |
| CHEMBL609 | TRIENTINE | 4.0 | 1 | 4.42 |
| CHEMBL1214193 | — | — | 1 | 4.30 |
| CHEMBL1214249 | — | — | 1 | 4.21 |
| CHEMBL1214322 | — | — | 1 | - |
| CHEMBL1214323 | — | — | 1 | - |
| CHEMBL1214321 | — | — | 1 | - |
| CHEMBL1214320 | — | — | 1 | - |
| CHEMBL14060 | PHENOL | 4.0 | 1 | - |
| CHEMBL209126 | — | — | 1 | - |
| CHEMBL1212954 | — | — | 1 | - |
| CHEMBL303429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119296 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1214194 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL1214195 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL303004 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL23194 | SPERMINE | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL25101 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL19612 | SPERMIDINE | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL1214248 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL609 | TRIENTINE | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL1214193 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL1214249 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL1214322 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214323 | — | Ki | = | 106000.0 | nM | - |
| CHEMBL1214321 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214320 | — | Ki | = | 416000.0 | nM | - |
| CHEMBL14060 | PHENOL | Ki | = | 218000.0 | nM | - |
| CHEMBL209126 | — | Ki | = | 131000.0 | nM | - |
| CHEMBL1212954 | — | Ki | = | 125000.0 | nM | - |
| CHEMBL303429 | — | Ki | = | 110000.0 | nM | - |