Assay Detail
Binding
CHEMBL1227597
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Inhibition of AChE by Ellman's assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.30 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.52 |
| CHEMBL564408 | — | — | 1 | 6.47 |
| CHEMBL1221975 | — | — | 1 | 6.41 |
| CHEMBL251077 | — | — | 1 | 6.37 |
| CHEMBL1222025 | — | — | 1 | 6.27 |
| CHEMBL558873 | — | — | 1 | 6.07 |
| CHEMBL1222026 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL564408 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL1221975 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL251077 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL1222025 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL558873 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL1222026 | — | Ki | = | 970.0 | nM | 6.01 |