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Assay Detail

CHEMBL1228967

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant PTP1B assessed as p-nitorphenol production after 30 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.
Li S, Li W, Wang Y, Asada Y, Koike K.
Bioorg Med Chem Lett (2010) 20 : 5398 -5401
PubMed 20724155 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 4.52 5.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL426373 1 5.36
CHEMBL1223582 GLYCYBENZOFURAN 1 4.59
CHEMBL1223641 GLISOFLAVONE 1 4.55
CHEMBL506929 LICOFLAVANONE A 1 4.26
CHEMBL491515 GLYCYRRHISOFLAVONE 1 4.23
CHEMBL611368 LICOCOUMARONE 1 4.15
CHEMBL1223642 GLYCYCOUMARIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL426373 IC50 = 4400.0 nM 5.36
CHEMBL1223582 GLYCYBENZOFURAN IC50 = 25500.0 nM 4.59
CHEMBL1223641 GLISOFLAVONE IC50 = 27900.0 nM 4.55
CHEMBL506929 LICOFLAVANONE A IC50 = 54500.0 nM 4.26
CHEMBL491515 GLYCYRRHISOFLAVONE IC50 = 58700.0 nM 4.23
CHEMBL611368 LICOCOUMARONE IC50 = 71200.0 nM 4.15
CHEMBL1223642 GLYCYCOUMARIN IC50 = 183900.0 nM -