Assay Detail
Binding
CHEMBL1243699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of UCHL1 in human H1299 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H1299 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (CHEMBL6159) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mechanisms, biology and inhibitors of deubiquitinating enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.58 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241672 | — | — | 1 | 6.09 |
| CHEMBL1241673 | — | — | 1 | 6.06 |
| CHEMBL1241765 | — | — | 1 | 6.03 |
| CHEMBL1241028 | — | — | 1 | 4.12 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | - |
| CHEMBL1241766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241672 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1241673 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL1241765 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1241028 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL590 | MENADIONE | IC50 | = | 290000.0 | nM | - |
| CHEMBL1241766 | — | IC50 | = | 126000.0 | nM | - |