Compound Detail
CHEMBL1241672
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Basic Information
| ChEMBL ID | CHEMBL1241672 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IJFMLJQTZKPAMK-LTGZKZEYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
442.1
MW (Da)
4.57
ALogP
4
HBA
0
HBD
59.0
PSA (Ų)
0.52
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 CHEMBL6159 | IC50 | 6.09 | 6.09 | 810.0 | 2 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 CHEMBL6195 | IC50 | 4.77 | 4.77 | 17000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | IC50 | = | 810.0 | nM | 6.09 | Inhibition of UCHL1 in human H1299 cells | 17948018 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | IC50 | = | 810.0 | nM | 6.09 | Inhibition of UCH-L1 (unknown origin) expressed in Escherichia coli BL21 (DE3) | 38262120 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 | IC50 | = | 17000.0 | nM | 4.77 | Inhibition of UCHL3 in human H1299 cells | 17948018 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17948018 | 10.1038/nchembio.2007.43 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 1 |
| 17948018 | 10.1038/nchembio.2007.43 | Ubiquitin carboxyl-terminal hydrolase isozyme L3 | 1 |
| 38262120 | 10.1016/j.ejmech.2024.116161 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 1 |
Data from ChEMBL 36 via Core Engine