Assay Detail
Binding
CHEMBL1246850
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Inhibition of sheep COX1 by spectrophotometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.54 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175 | DEXIBUPROFEN | 4.0 | 1 | 5.50 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.16 |
| CHEMBL7162 | NS-398 | — | 1 | 4.85 |
| CHEMBL1240887 | — | — | 1 | 4.82 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 4.63 |
| CHEMBL1243098 | — | — | 1 | 4.57 |
| CHEMBL1243067 | — | — | 1 | 4.46 |
| CHEMBL1243065 | — | — | 1 | 4.12 |
| CHEMBL1240964 | — | — | 1 | 4.10 |
| CHEMBL1243100 | — | — | 1 | 4.10 |
| CHEMBL1240963 | — | — | 1 | 4.07 |
| CHEMBL1240924 | — | — | 1 | 4.05 |
| CHEMBL1240925 | — | — | 1 | - |
| CHEMBL1243099 | — | — | 1 | - |
| CHEMBL1240923 | — | — | 1 | - |
| CHEMBL1240922 | — | — | 1 | - |
| CHEMBL1240889 | — | — | 1 | - |
| CHEMBL1240888 | — | — | 1 | - |
| CHEMBL1243066 | — | — | 1 | - |
| CHEMBL1240537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175 | DEXIBUPROFEN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL118 | CELECOXIB | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL7162 | NS-398 | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL1240887 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL1243098 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL1243067 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL1243065 | — | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL1240964 | — | IC50 | = | 78700.0 | nM | 4.10 |
| CHEMBL1243100 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1240963 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL1240924 | — | IC50 | = | 89600.0 | nM | 4.05 |
| CHEMBL1240925 | — | IC50 | = | 140700.0 | nM | - |
| CHEMBL1243099 | — | IC50 | = | 177300.0 | nM | - |
| CHEMBL1240923 | — | IC50 | = | 106500.0 | nM | - |
| CHEMBL1240922 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL1240889 | — | IC50 | = | 143700.0 | nM | - |
| CHEMBL1240888 | — | IC50 | = | 231200.0 | nM | - |
| CHEMBL1243066 | — | IC50 | = | 183000.0 | nM | - |
| CHEMBL1240537 | — | IC50 | = | 150000.0 | nM | - |