Assay Detail
Binding
CHEMBL1261014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system by surface plasmon resonance biosensor assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lymnaea stagnalis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 22 | 5.75 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1258006 | BRADANICLINE | 2.0 | 1 | 7.70 |
| CHEMBL1258240 | — | — | 1 | 7.62 |
| CHEMBL1258005 | — | — | 1 | 7.03 |
| CHEMBL1258126 | — | — | 1 | 7.00 |
| CHEMBL1257896 | — | — | 1 | 6.66 |
| CHEMBL1258125 | — | — | 1 | 6.62 |
| CHEMBL1256001 | — | — | 1 | 6.50 |
| CHEMBL1258358 | — | — | 1 | 6.46 |
| CHEMBL1258241 | — | — | 1 | 6.36 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.32 |
| CHEMBL1256002 | — | — | 1 | 6.26 |
| CHEMBL1258127 | — | — | 1 | 6.06 |
| CHEMBL177611 | PNU-282987 | — | 1 | 5.44 |
| CHEMBL1255908 | — | — | 1 | 5.35 |
| CHEMBL1256000 | — | — | 1 | 5.31 |
| CHEMBL142049 | — | — | 1 | 5.22 |
| CHEMBL1255909 | — | — | 1 | 4.73 |
| CHEMBL1255907 | — | — | 1 | 4.53 |
| CHEMBL1255823 | — | — | 1 | 4.30 |
| CHEMBL1256003 | — | — | 1 | 4.13 |
| CHEMBL1256004 | — | — | 1 | 3.83 |
| CHEMBL1255822 | — | — | 1 | 3.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1258006 | BRADANICLINE | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL1258240 | — | Kd | = | 23.99 | nM | 7.62 |
| CHEMBL1258005 | — | Kd | = | 93.33 | nM | 7.03 |
| CHEMBL1258126 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL1257896 | — | Kd | = | 218.78 | nM | 6.66 |
| CHEMBL1258125 | — | Kd | = | 239.88 | nM | 6.62 |
| CHEMBL1256001 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL1258358 | — | Kd | = | 346.74 | nM | 6.46 |
| CHEMBL1258241 | — | Kd | = | 436.52 | nM | 6.36 |
| CHEMBL3 | NICOTINE | Kd | = | 478.63 | nM | 6.32 |
| CHEMBL1256002 | — | Kd | = | 549.54 | nM | 6.26 |
| CHEMBL1258127 | — | Kd | = | 870.96 | nM | 6.06 |
| CHEMBL177611 | PNU-282987 | Kd | = | 3630.78 | nM | 5.44 |
| CHEMBL1255908 | — | Kd | = | 4466.84 | nM | 5.35 |
| CHEMBL1256000 | — | Kd | = | 4897.79 | nM | 5.31 |
| CHEMBL142049 | — | Kd | = | 6025.6 | nM | 5.22 |
| CHEMBL1255909 | — | Kd | = | 18620.87 | nM | 4.73 |
| CHEMBL1255907 | — | Kd | = | 29512.09 | nM | 4.53 |
| CHEMBL1255823 | — | Kd | = | 50118.72 | nM | 4.30 |
| CHEMBL1256003 | — | Kd | = | 74131.02 | nM | 4.13 |
| CHEMBL1256004 | — | Kd | = | 147910.84 | nM | 3.83 |
| CHEMBL1255822 | — | Kd | = | 741310.24 | nM | 3.13 |