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Compound Detail

CHEMBL1256001

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O[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1

Basic Information

ChEMBL ID CHEMBL1256001
Phase Preclinical
Structure Type MOL
InChI Key CKDDUULIRPQPSS-QWHCGFSZSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

218.3
MW (Da)
1.08
ALogP
3
HBA
1
HBD
36.4
PSA (Ų)
0.81
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H18N2O
MW 218.30
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness 0.28

Activity Summary

Kd 2 meas. best 6.5
Ki 2 meas. best 6.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholine-binding protein
CHEMBL6084
Ki 6.6 6.6 251.2 1
Acetylcholine-binding protein
CHEMBL6084
Kd 6.5 6.5 316.2 1
Unchecked
CHEMBL612545
Kd 5.88 5.88 1318.3 1
Neuronal acetylcholine receptor subunit alpha-7
CHEMBL2492
Ki 5.48 5.48 3311.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20828128 10.1021/jm100834y Acetylcholine-binding protein 2
20828128 10.1021/jm100834y Unchecked 1
20828128 10.1021/jm100834y Neuronal acetylcholine receptor subunit alpha-7 1

Data from ChEMBL 36 via Core Engine