Assay Detail
Functional
CHEMBL1273274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antithrombotic activity in iv dosed rabbit assessed as restoration of integrated blood flow
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Factor Xa inhibitors: next-generation antithrombotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 2 | - | - |
| EC50 | 1 | 6.86 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176140 | — | — | 1 | 6.86 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | - |
| CHEMBL231779 | APIXABAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176140 | — | EC50 | = | 137.0 | nM | 6.86 |
| CHEMBL206335 | RAZAXABAN | ED50 | = | 0.22 | mg/kg/hr | - |
| CHEMBL231779 | APIXABAN | ED50 | = | 0.07 | mg/kg/hr | - |