Assay Detail
ADMET
CHEMBL1273327
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Cytotoxicity against human HuH7 cells assessed as release of lactate dehydrogenase
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.59 | 5.83 |
| IC90 | 20 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269594 | — | — | 2 | 5.83 |
| CHEMBL1269579 | — | — | 2 | 5.76 |
| CHEMBL1269595 | — | — | 2 | 5.74 |
| CHEMBL1269580 | — | — | 2 | 5.70 |
| CHEMBL1269589 | — | — | 2 | 5.69 |
| CHEMBL1269581 | — | — | 2 | 5.68 |
| CHEMBL1269591 | — | — | 2 | 5.67 |
| CHEMBL1269596 | — | — | 2 | 5.65 |
| CHEMBL1269584 | — | — | 2 | 5.62 |
| CHEMBL1269582 | — | — | 2 | 5.59 |
| CHEMBL1269593 | — | — | 2 | 5.57 |
| CHEMBL1269583 | — | — | 2 | 5.55 |
| CHEMBL1269592 | — | — | 2 | 5.55 |
| CHEMBL1269590 | — | — | 2 | 5.49 |
| CHEMBL1269585 | — | — | 2 | 5.34 |
| CHEMBL1269586 | — | — | 2 | 5.28 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 2 | 5.24 |
| CHEMBL1269587 | — | — | 2 | - |
| CHEMBL1269588 | — | — | 2 | - |
| CHEMBL1269597 | SCY 635 | 2.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269594 | — | IC50 | = | 1496.0 | nM | 5.83 |
| CHEMBL1269579 | — | IC50 | = | 1719.0 | nM | 5.76 |
| CHEMBL1269595 | — | IC50 | = | 1817.0 | nM | 5.74 |
| CHEMBL1269580 | — | IC50 | = | 2015.0 | nM | 5.70 |
| CHEMBL1269589 | — | IC50 | = | 2054.0 | nM | 5.69 |
| CHEMBL1269581 | — | IC50 | = | 2069.0 | nM | 5.68 |
| CHEMBL1269591 | — | IC50 | = | 2154.0 | nM | 5.67 |
| CHEMBL1269596 | — | IC50 | = | 2239.0 | nM | 5.65 |
| CHEMBL1269584 | — | IC50 | = | 2371.0 | nM | 5.62 |
| CHEMBL1269582 | — | IC50 | = | 2565.0 | nM | 5.59 |
| CHEMBL1269593 | — | IC50 | = | 2683.0 | nM | 5.57 |
| CHEMBL1269592 | — | IC50 | = | 2807.0 | nM | 5.55 |
| CHEMBL1269583 | — | IC50 | = | 2818.0 | nM | 5.55 |
| CHEMBL1269590 | — | IC50 | = | 3275.0 | nM | 5.49 |
| CHEMBL1269585 | — | IC50 | = | 4612.0 | nM | 5.34 |
| CHEMBL1269586 | — | IC50 | = | 5303.0 | nM | 5.28 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL1269587 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1269588 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1269597 | SCY 635 | IC50 | > | 10000.0 | nM | - |
| CHEMBL1269579 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269580 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269581 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269582 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269583 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269584 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269585 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269586 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269587 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL160 | CYCLOSPORINE | IC90 | = | 18750.0 | nM | - |
| CHEMBL1269597 | SCY 635 | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269595 | — | IC90 | = | 8913.0 | nM | - |
| CHEMBL1269594 | — | IC90 | = | 8620.0 | nM | - |
| CHEMBL1269593 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269592 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269591 | — | IC90 | = | 8733.0 | nM | - |
| CHEMBL1269590 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269589 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269588 | — | IC90 | > | 10000.0 | nM | - |
| CHEMBL1269596 | — | IC90 | = | 7897.0 | nM | - |