Assay Detail
Functional
CHEMBL1273346
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Antithrombotic activity in rabbit arteriovenous-shunt thrombosis model measured per hr
6
Total Activities
6
Compounds Tested
4
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Factor Xa inhibitors: next-generation antithrombotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 2 | - | - |
| ID50 | 2 | - | - |
| IC50 | 1 | 6.30 | 6.30 |
| EC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222079 | — | — | 1 | 6.30 |
| CHEMBL231779 | APIXABAN | 4.0 | 1 | - |
| CHEMBL198362 | RIVAROXABAN | 4.0 | 1 | - |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | - |
| CHEMBL151939 | — | — | 1 | - |
| CHEMBL476186 | ERIBAXABAN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222079 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL231779 | APIXABAN | ED50 | = | 0.27 | mg.kg-1 | - |
| CHEMBL198362 | RIVAROXABAN | ED50 | = | 0.6 | mg.kg-1 | - |
| CHEMBL206335 | RAZAXABAN | ID50 | = | 0.0016 | umol.kg-1 | - |
| CHEMBL151939 | — | ID50 | = | 0.0042 | umol.kg-1 | - |
| CHEMBL476186 | ERIBAXABAN | EC50 | = | 0.055 | ug.mL-1 | - |