Assay Detail

CHEMBL1273374

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to Hsp90 nucleotide binding domain

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Heat shock protein HSP 90-beta (CHEMBL4303) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Heat shock protein HSP 90-beta (CHEMBL4303) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Heat shock protein HSP 90-beta

CHEMBL4303

Anchored from Assay target.

Protein identity Heat shock protein HSP 90-beta

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Heat shock protein HSP 90-beta (CHEMBL4303) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

ATPases as drug targets: insights from heat shock proteins 70 and 90.

Massey AJ.
J Med Chem (2010) 53 : 7280 -7286
PubMed 20608738 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	8.77	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL252164	LUMINESPIB	2.0	1	8.77
CHEMBL467399	BIIB021	2.0	1	8.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL252164	LUMINESPIB	Kd	=	1.7	nM	8.77
CHEMBL467399	BIIB021	Kd	=	1.7	nM	8.77