Assay Detail
Binding
CHEMBL1274064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.11 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1271961 | — | — | 1 | 8.45 |
| CHEMBL1271906 | — | — | 1 | 7.88 |
| CHEMBL1271907 | — | — | 1 | 7.42 |
| CHEMBL1271793 | — | — | 1 | 6.68 |
| CHEMBL65239 | — | — | 1 | 6.58 |
| CHEMBL1271850 | — | — | 1 | 6.57 |
| CHEMBL277630 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1271961 | — | Ki | = | 3.57 | nM | 8.45 |
| CHEMBL1271906 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL1271907 | — | Ki | = | 38.1 | nM | 7.42 |
| CHEMBL1271793 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL65239 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL1271850 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL277630 | — | Ki | = | 652.0 | nM | 6.19 |