Assay Detail
Functional
CHEMBL1284240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against herpes simplex virus 1 E-377 infected in HFF cells by plaque reduction assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.14 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502317 | — | — | 1 | 7.00 |
| CHEMBL473586 | — | — | 1 | 6.22 |
| CHEMBL1276695 | — | — | 1 | 5.92 |
| CHEMBL223160 | — | — | 1 | 5.40 |
| CHEMBL1275686 | — | — | 1 | - |
| CHEMBL63849 | — | — | 1 | - |
| CHEMBL418216 | — | — | 1 | - |
| CHEMBL1276696 | — | — | 1 | - |
| CHEMBL61733 | PMEDAP | — | 1 | - |
| CHEMBL1276665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502317 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL473586 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1276695 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL223160 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1275686 | — | EC50 | - | — | - | |
| CHEMBL63849 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL418216 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL1276696 | — | EC50 | > | 12000.0 | nM | - |
| CHEMBL61733 | PMEDAP | EC50 | > | 10000.0 | nM | - |
| CHEMBL1276665 | — | EC50 | = | 260000.0 | nM | - |