Compound Detail
CHEMBL63849
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL63849 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OQKZMUKOVUOYMR-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names
Molecular Properties
328.1
MW (Da)
-0.26
ALogP
6
HBA
3
HBD
127.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 4.62 | 4.62 | 24000.0 | 1 |
| Human alphaherpesvirus 3 CHEMBL613132 | EC50 | 4.42 | 4.42 | 38000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | EC50 | = | 24000.0 | nM | 4.62 | Antiviral activity against Epstein-Barr virus p3hr-1 infected in human daudi cel... | 18852272 |
| Human alphaherpesvirus 3 | EC50 | = | 38000.0 | nM | 4.42 | Antiviral activity against Varicella zoster virus Ellen infected in HFF cells by... | 18852272 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18852272 | 10.1128/aac.00918-08 | Unchecked | 8 |
| 18852272 | 10.1128/aac.00918-08 | NON-PROTEIN TARGET | 5 |
| 10377214 | 10.1021/jm9811256 | Human herpesvirus 3 deoxypyrimidine kinase | 4 |
| 10377214 | 10.1021/jm9811256 | Human alphaherpesvirus 1 | 3 |
| 18852272 | 10.1128/aac.00918-08 | HFF | 2 |
| 10377214 | 10.1021/jm9811256 | Cytomegalovirus | 2 |
| 10377214 | 10.1021/jm9811256 | Thymidine kinase | 2 |
| 10377214 | 10.1021/jm9811256 | Unchecked | 2 |
| 10377214 | 10.1021/jm9811256 | Human alphaherpesvirus 2 | 2 |
| 10377214 | 10.1021/jm9811256 | Vaccinia virus | 1 |
| 10377214 | 10.1021/jm9811256 | Human immunodeficiency virus 1 | 1 |
| 10377214 | 10.1021/jm9811256 | Human immunodeficiency virus 2 | 1 |
| 18852272 | 10.1128/aac.00918-08 | Human betaherpesvirus 5 | 1 |
| 18852272 | 10.1128/aac.00918-08 | Human alphaherpesvirus 3 | 1 |
| 18852272 | 10.1128/aac.00918-08 | Human alphaherpesvirus 2 | 1 |
| 18852272 | 10.1128/aac.00918-08 | Human alphaherpesvirus 1 | 1 |
| 18852272 | 10.1128/aac.00918-08 | MOLT-3 | 1 |
| 18852272 | 10.1128/aac.00918-08 | Daudi | 1 |
Data from ChEMBL 36 via Core Engine