Assay Detail
Functional
CHEMBL1284246
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Antiviral activity against Human cytomegalovirus AD169 infected in HFF cells by plaque reduction assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.05 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502317 | — | — | 1 | 7.70 |
| CHEMBL223160 | — | — | 1 | 6.40 |
| CHEMBL473586 | — | — | 1 | 6.30 |
| CHEMBL1276696 | — | — | 1 | 5.70 |
| CHEMBL1276695 | — | — | 1 | 5.32 |
| CHEMBL61733 | PMEDAP | — | 1 | 4.89 |
| CHEMBL1275686 | — | — | 1 | - |
| CHEMBL63849 | — | — | 1 | - |
| CHEMBL1276665 | — | — | 1 | - |
| CHEMBL418216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502317 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL223160 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL473586 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1276696 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1276695 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL61733 | PMEDAP | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1275686 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL63849 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1276665 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL418216 | — | EC50 | > | 20000.0 | nM | - |