Assay Detail
Binding
CHEMBL1286520
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Non-competitive inhibition of SARS coronavirus 3C-like protease by Dixon plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.48 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 4.86 |
| CHEMBL377324 | GINKGETIN | — | 1 | 4.52 |
| CHEMBL208908 | SCIADOPITISIN | — | 1 | 4.45 |
| CHEMBL378188 | BILOBETIN | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | Ki | = | 13800.0 | nM | 4.86 |
| CHEMBL377324 | GINKGETIN | Ki | = | 30200.0 | nM | 4.52 |
| CHEMBL208908 | SCIADOPITISIN | Ki | = | 35600.0 | nM | 4.45 |
| CHEMBL378188 | BILOBETIN | Ki | = | 80400.0 | nM | 4.09 |