Assay Detail
Binding
CHEMBL1286522
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Inhibition of SARS coronavirus 3C-like protease after 60 mins by FRET assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.54 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 5.08 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.70 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.62 |
| CHEMBL377324 | GINKGETIN | — | 1 | 4.50 |
| CHEMBL208908 | SCIADOPITISIN | — | 1 | 4.42 |
| CHEMBL197308 | FERRUGINOL | — | 1 | 4.30 |
| CHEMBL378188 | BILOBETIN | — | 1 | 4.14 |
| CHEMBL197310 | 18-HYDROXYFERRUGINOL | — | 1 | - |
| CHEMBL1277661 | HINOKIOL | — | 1 | - |
| CHEMBL1277662 | 18-OXOFERRUGINOL | — | 1 | - |
| CHEMBL1277754 | — | — | 1 | - |
| CHEMBL12798 | METHYL DEHYDROABIETATE | — | 1 | - |
| CHEMBL512164 | ISOPIMARIC ACID | — | 1 | - |
| CHEMBL1277840 | KAYADIOL | — | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
| CHEMBL71893 | ABIETIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL50 | QUERCETIN | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL377324 | GINKGETIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL208908 | SCIADOPITISIN | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL197308 | FERRUGINOL | IC50 | = | 49600.0 | nM | 4.30 |
| CHEMBL378188 | BILOBETIN | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL197310 | 18-HYDROXYFERRUGINOL | IC50 | = | 220800.0 | nM | - |
| CHEMBL1277661 | HINOKIOL | IC50 | = | 233400.0 | nM | - |
| CHEMBL1277662 | 18-OXOFERRUGINOL | IC50 | = | 163200.0 | nM | - |
| CHEMBL1277754 | — | IC50 | = | 128900.0 | nM | - |
| CHEMBL12798 | METHYL DEHYDROABIETATE | IC50 | = | 207000.0 | nM | - |
| CHEMBL512164 | ISOPIMARIC ACID | IC50 | = | 283500.0 | nM | - |
| CHEMBL1277840 | KAYADIOL | IC50 | = | 137700.0 | nM | - |
| CHEMBL28 | APIGENIN | IC50 | = | 280800.0 | nM | - |
| CHEMBL71893 | ABIETIC ACID | IC50 | = | 189100.0 | nM | - |