Assay Detail
Binding
CHEMBL1291430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of new spirocyclic muscarinic M3 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 10.13 | 10.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 10.50 |
| CHEMBL551466 | ACLIDINIUM BROMIDE | 4.0 | 1 | 10.00 |
| CHEMBL1201027 | GLYCOPYRRONIUM BROMIDE | 4.0 | 1 | 9.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | IC50 | = | 0.03162 | nM | 10.50 |
| CHEMBL551466 | ACLIDINIUM BROMIDE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1201027 | GLYCOPYRRONIUM BROMIDE | IC50 | = | 0.1259 | nM | 9.90 |