Assay Detail
ADMET
CHEMBL1293108
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Inhibition of CYP3A4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.76 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214957 | — | — | 1 | 5.80 |
| CHEMBL1290150 | — | — | 1 | 5.77 |
| CHEMBL1290041 | — | — | 1 | 5.70 |
| CHEMBL1289614 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214957 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1290150 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1290041 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1289614 | — | IC50 | < | 50.0 | nM | - |