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Assay Detail

CHEMBL1613835

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Image-Based HTS for Selective Antagonists of GPR35. High content imaging assay of the inhibition of receptor-mediated beta-arrestin GFP translocation to cytosolic compartments Secondary Screen (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2079, AID2397, AID2480, AID463201, AID463202, AID463217, AID463227, AID463228, AID488987]
ChEMBL ↗
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

G-protein coupled receptor 35 (CHEMBL1293267) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 98 5.77 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1386711 — — 1 6.28
CHEMBL1424929 — — 1 6.27
CHEMBL1500763 — — 1 6.26
CHEMBL1353925 — — 1 6.25
CHEMBL1532025 — — 1 6.25
CHEMBL1487024 — — 1 6.25
CHEMBL1372770 — — 1 6.25
CHEMBL1304179 — — 1 6.24
CHEMBL1442537 — — 1 6.21
CHEMBL1325250 — — 1 6.21
CHEMBL1307717 — — 1 6.20
CHEMBL1303807 — — 1 6.19
CHEMBL1300169 — — 1 6.15
CHEMBL1312928 — — 1 6.13
CHEMBL1368962 — — 1 6.12
CHEMBL1428840 — — 1 6.12
CHEMBL1430125 — — 1 6.10
CHEMBL1444708 — — 1 6.09
CHEMBL1560901 — — 1 6.09
CHEMBL1464544 — — 1 6.08
CHEMBL1975147 — — 1 6.05
CHEMBL1333832 — — 1 6.03
CHEMBL466853 — — 1 6.00
CHEMBL1494365 — — 1 6.00
CHEMBL1497386 — — 1 6.00
CHEMBL1420573 — — 1 6.00
CHEMBL1510156 — — 1 5.97
CHEMBL1492565 — — 1 5.96
CHEMBL1716874 — — 1 5.96
CHEMBL1547464 — — 1 5.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1386711 — IC50 = 529.71 nM 6.28
CHEMBL1424929 — IC50 = 533.78 nM 6.27
CHEMBL1500763 — IC50 = 553.11 nM 6.26
CHEMBL1353925 — IC50 = 556.59 nM 6.25
CHEMBL1532025 — IC50 = 562.83 nM 6.25
CHEMBL1487024 — IC50 = 563.64 nM 6.25
CHEMBL1372770 — IC50 = 560.66 nM 6.25
CHEMBL1304179 — IC50 = 573.4 nM 6.24
CHEMBL1442537 — IC50 = 609.68 nM 6.21
CHEMBL1325250 — IC50 = 615.09 nM 6.21
CHEMBL1307717 — IC50 = 626.47 nM 6.20
CHEMBL1303807 — IC50 = 650.6 nM 6.19
CHEMBL1300169 — IC50 = 701.49 nM 6.15
CHEMBL1312928 — IC50 = 744.16 nM 6.13
CHEMBL1428840 — IC50 = 760.98 nM 6.12
CHEMBL1368962 — IC50 = 768.05 nM 6.12
CHEMBL1430125 — IC50 = 786.83 nM 6.10
CHEMBL1444708 — IC50 = 804.54 nM 6.09
CHEMBL1560901 — IC50 = 802.74 nM 6.09
CHEMBL1464544 — IC50 = 834.53 nM 6.08
CHEMBL1975147 — IC50 = 898.37 nM 6.05
CHEMBL1333832 — IC50 = 929.42 nM 6.03
CHEMBL1420573 — IC50 = 1008.69 nM 6.00
CHEMBL1497386 — IC50 = 990.68 nM 6.00
CHEMBL466853 — IC50 = 1010.37 nM 6.00
CHEMBL1494365 — IC50 = 1004.13 nM 6.00
CHEMBL1510156 — IC50 = 1066.27 nM 5.97
CHEMBL1492565 — IC50 = 1103.97 nM 5.96
CHEMBL1716874 — IC50 = 1107.14 nM 5.96
CHEMBL1547464 — IC50 = 1119.73 nM 5.95
CHEMBL1490312 — IC50 = 1122.06 nM 5.95
CHEMBL3198952 — IC50 = 1158.43 nM 5.94
CHEMBL1333032 — IC50 = 1162.03 nM 5.93
CHEMBL1532412 — IC50 = 1191.15 nM 5.92
CHEMBL1387336 — IC50 = 1198.36 nM 5.92
CHEMBL1357976 — IC50 = 1263.19 nM 5.90
CHEMBL1351967 — IC50 = 1327.82 nM 5.88
CHEMBL1523126 — IC50 = 1313.31 nM 5.88
CHEMBL1431610 — IC50 = 1370.69 nM 5.86
CHEMBL1412529 — IC50 = 1424.12 nM 5.85
CHEMBL1308547 — IC50 = 1437.32 nM 5.84
CHEMBL3209511 — IC50 = 1490.8 nM 5.83
CHEMBL1595152 — IC50 = 1463.84 nM 5.83
CHEMBL1387749 — IC50 = 1509.73 nM 5.82
CHEMBL1369492 — IC50 = 1593.44 nM 5.80
CHEMBL1517609 — IC50 = 1622.95 nM 5.79
CHEMBL1498210 — IC50 = 1665.61 nM 5.78
CHEMBL1970711 — IC50 = 1759.05 nM 5.75
CHEMBL1550295 — IC50 = 1778.72 nM 5.75
CHEMBL1572785 — IC50 = 1816.12 nM 5.74